Hong Kong News

Nonpartisan, Noncommercial, unconstrained.
Saturday, Apr 13, 2024

'Functional cure' in the works for hepatitis B

'Functional cure' in the works for hepatitis B

Some 570,000 hepatitis B carriers in Hong Kong may be freed from life-long medication and see their liver cancer and cirrhosis risks reduced in the next decade with University of Hong Kong researchers completing development of a new therapy to achieve "functional cure."
Gastroenterology and hepatology chief and research leader Yuen Man-fung said hepatitis B sufferers here rely on life-long oral medication to suppress their viral load.

If their conditions are untreated or do not improve, one in three would develop complications, including liver cirrhosis and cancer. Every year, 820,000 lives are estimated to be claimed by hepatitis B worldwide.

Yuen said the goal of the drug is to buy time to achieve a "functional cure" to suppress patients' viral load to a minimal, or even undetectable, level.

Antigens on the surface of hepatitis B viruses - which "hypnotize" patients' immune system to favor viral replication - will also be suppressed to a minimal level.

In the absence of the antigen, the immune system will "wake up" and fight the virus itself, and patients will no longer have to take medication for life.

Yuen said his team has taken the drug to phase two clinical trials and found around one in 10 recipients saw lower viral loads upon receiving a dose of 300mg of the drug per week over a period of 24 weeks.

Among test subjects with lower viral loads to begin with, up to one in four saw consistently lowered viral levels. After 24 weeks, 80 to 90 percent of them no longer require lifelong medications.

He said a phase three trial will be conducted and that it will take at least three to five more years to further assess the drug's effectiveness and safety before it can be approved for full clinical use.

Yuen said his team will also focus on combining different medications to push the "functional cure" success rate to 30 percent.

He hopes the final product will consist of no more than three types of medications, and that patients only need to take them for two years or less.

He said HKU currently takes part in over 80 percent of international hepatitis B trials - including 58 over the past eight years - proving its leading position in the field.

Related Articles

Hong Kong News
It's always the people with the dirty hands pointing their fingers
Paper straws found to contain long-lasting and potentially toxic chemicals - study
FTX's Bankman-Fried headed for jail after judge revokes bail
Blackrock gets half a trillion dollar deal to rebuild Ukraine
Steve Jobs' Son Launches Venture Capital Firm With $200 Million For Cancer Treatments
Google reshuffles Assistant unit, lays off some staffers, to 'supercharge' products with A.I.
End of Viagra? FDA approved a gel against erectile dysfunction
UK sanctions Russians judges over dual British national Kara-Murza's trial
US restricts visa-free travel for Hungarian passport holders because of security concerns
America's First New Nuclear Reactor in Nearly Seven Years Begins Operations
Southeast Asia moves closer to economic unity with new regional payments system
Political leader from South Africa, Julius Malema, led violent racist chants at a massive rally on Saturday
Today Hunter Biden’s best friend and business associate, Devon Archer, testified that Joe Biden met in Georgetown with Russian Moscow Mayor's Wife Yelena Baturina who later paid Hunter Biden $3.5 million in so called “consulting fees”
'I am not your servant': IndiGo crew member, passenger get into row over airline meal
Singapore Carries Out First Execution of a Woman in Two Decades Amid Capital Punishment Debate
Spanish Citizenship Granted to Iranian chess player who removed hijab
US Senate Republican Mitch McConnell freezes up, leaves press conference
Speaker McCarthy says the United States House of Representatives is getting ready to impeach Joe Biden.
San Francisco car crash
This camera man is a genius
3D ad in front of Burj Khalifa
Next level gaming
BMW driver…
Google testing journalism AI. We are doing it already 2 years, and without Google biased propoganda and manipulated censorship
Unlike illegal imigrants coming by boats - US Citizens Will Need Visa To Travel To Europe in 2024
Musk announces Twitter name and logo change to X.com
The politician and the journalist lost control and started fighting on live broadcast.
The future of sports
Unveiling the Black Hole: The Mysterious Fate of EU's Aid to Ukraine
Farewell to a Music Titan: Tony Bennett, Renowned Jazz and Pop Vocalist, Passes Away at 96
Alarming Behavior Among Florida's Sharks Raises Concerns Over Possible Cocaine Exposure
Transgender Exclusion in Miss Italy Stirs Controversy Amidst Changing Global Beauty Pageant Landscape
Joe Biden admitted, in his own words, that he delivered what he promised in exchange for the $10 million bribe he received from the Ukraine Oil Company.
TikTok Takes On Spotify And Apple, Launches Own Music Service
Global Trend: Using Anti-Fake News Laws as Censorship Tools - A Deep Dive into Tunisia's Scenario
Arresting Putin During South African Visit Would Equate to War Declaration, Asserts President Ramaphosa
Hacktivist Collective Anonymous Launches 'Project Disclosure' to Unearth Information on UFOs and ETIs
Typo sends millions of US military emails to Russian ally Mali
Server Arrested For Theft After Refusing To Pay A Table's $100 Restaurant Bill When They Dined & Dashed
The Changing Face of Europe: How Mass Migration is Reshaping the Political Landscape
China Urges EU to Clarify Strategic Partnership Amid Trade Tensions
The Last Pour: Anchor Brewing, America's Pioneer Craft Brewer, Closes After 127 Years
Democracy not: EU's Digital Commissioner Considers Shutting Down Social Media Platforms Amid Social Unrest
Sarah Silverman and Renowned Authors Lodge Copyright Infringement Case Against OpenAI and Meta
Why Do Tech Executives Support Kennedy Jr.?
The New York Times Announces Closure of its Sports Section in Favor of The Athletic
BBC Anchor Huw Edwards Hospitalized Amid Child Sex Abuse Allegations, Family Confirms
Florida Attorney General requests Meta CEO's testimony on company's platforms' alleged facilitation of illicit activities
The Distorted Mirror of actual approval ratings: Examining the True Threat to Democracy Beyond the Persona of Putin
40,000 child slaves in Congo are forced to work in cobalt mines so we can drive electric cars.