The owner of the Daily Mail, DMGT, has bought the i newspaper and website for £49.6m from JPI Media.
DMGT chairman Lord Rothermere said the paper was "a highly respected publication with a loyal and engaged readership".
"We are committed to preserving its distinctive, high-quality and politically independent editorial style."
The Competition and Markets Authority will have to approve the deal.
In 2018, the i reported an operating profit of £11m from £34m in sales.
The deal means that the paper will have its fourth owner in as many years.
The sale was attacked by Labour leader Jeremy Corbyn, who said in a tweet that two billionaires now owned half the UK's top 10 daily newspapers.
The i was launched in 2010 as a sister paper to the Independent. It sells for 65p on weekdays and £1.20 on Saturdays.
When it first hit the newsstands, executives at the company said it was aimed at "time-poor newspaper readers", especially commuters, who lacked the time to read a quality newspaper on a regular basis.
At its launch, it shared the same editorial staff as its sister paper and was seen as a way of extending the Independent's brand to a new market.
But in 2016, the Independent closed its print edition and the i was sold for £24m to Johnston Press.
Despite this, links to the paper's former parent remained, with the i continuing to provide a print home for some of the Independent's now otherwise digital-only content.
God, please protect me from my friends. I can handle my enemies.